Product

UROTRACTIN

Category

Antibiotics & Chemotherapeutics

Type

Quinolones

Package

Box of 6 strips @ 10 capsules.
Reg. No.: DKL8522206201A1

Composition

Pipemidic acid 400 mg

Indication

Infections of the genitourinary tract caused by sensitive Gram-positive and Gram-negative microorganisms

Dossage

Adults: the recommended dose is one capsule twice
daily at 12 hours intervals, preferably after meals.
As with other urinary-tract infections it is advisable to
prolong treatment for at least 10 days to prevent the
possibility of recurrence.
In cases of chronic and recurrent infections,
UROTRACTIN can be administered for a prolonged
period and is well tolerated due to its low toxicity.
Children of over 14 years of age can follow the adult
dose. While taking UROTRACTIN , it is advisable not
to expose oneself for longer periods to the sun as there
is a risk of photosensitivity reaction with a possible consequence
of bullous dermatitis

Precaution

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AKILEN

Category

Antibiotics & Chemotherapeutics

Type

Quinolones

Package

AKILEN 200: Dus fill 3 strips @ 10 tablets.
No. Reg .: DKL9222213017A1
AKILEN 400: Dus fill 5 strips @ 6 tablets.
No. Reg .: DKL9522213017B1

Composition

Ofloksasin 200 mg / 400 mg

Indication

- Urinary tract infection
- Urethritis and gonococcal and non gonococcal servisitis.
- Lower respiratory tract infections.
- Skin and soft tissue infections.
- Infection of the womb, and bacterial enteritis.

Dossage

Adults:
- Urinary tract infections: 100 - 400 mg, 2 times daily
1 - 10 days. For severe and complicated infections: 600 mg
A day is given for 20 days.
- Respiratory tract infections: 200 - 400 mg, 2 times daily.
- Uncomplicated gonococcal urethritis and cervicitis
(Including PPNG infection): 200 - 600 mg as
Single dose.
- Non-gonococcal urethritis: 400 mg daily single dose
Or divided dose for 9 days.
- Skin and soft tissue infections, uterine infections, and
Bacterial enteritis: 400 mg daily, for 7 days.
For patients with decreased renal function, interval
Dosing extended to 24 hours
When creatinine clearance is between 20 - 80 ml / min, and
Extended to 36 to 48 hours when clearance
Creatinine less than 20 ml / min.

Precaution

ATTENTION
1. When hypersensitive reactions occur and symptoms resemble
Shock, treatment stopped.
2. Given with caution in sufferers with
Decreased kidney function, and adjust dose to
Severe renal dysfunction. Elderly sufferers may
Require dose reduction, as it usually is
Creatinine clearance has decreased.
3. Be careful when given during childbearing.
4. Absorption in the intestine will decrease when given
Together with antacids containing
Aluminum or magnesium hydroxide. Because it is given
1 - 2 hours before or after Ofloxacin.

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Amoxsan 250 mg

Category

Antibiotics & Chemotherapeutics

Type

Beta-Lactams Penicillin

Package

Box of 10 strips @ 10 tablets. Lic. No. : DKL0732401281A1

Composition

Each tablet contains Amoxicillin Trihydrate USP equivalent to 250 mg of Amoxicillin.

Indication

AMOXSAN Dispersible Tablet is a broad spectrum antibiotic indicated for the treatment of commonly occurring bacterial infections such a :
• Upper respiratory tract infections e.g., tonsillitis, sinusitis, otitis media.
• Lower respiratory tract infections e.g., acute and chronic bronchitis, lobar and bronchopneumonia.
• Genito-urinary tract infections e.g. cystitis, urethritis, pyelonephritis, septic abortion, puerperal sepsis.
• Skin and soft tissue infections.
• Bone infections.
• Gonorrhoea (non-penicillinase producing strains)
• Dental abscess (as an adjunct to surgical management).
• Strains of the following organisms are generally sensi®ti ve to the bactericidal action of AMOXSAN in vitro :

Gram-positive
Aerobes : Streptococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, penicillin-sensitive Staphylococcus aureus, Coryne-bacterium species, Bacillus anthracis, Listeria monocytogenes.

Anaerobes : Clostridium species.

Gram-negave
Aerobes : Haemophilus influenza, Eschericia coli, Proteus mirabilis, Salmonella species, Shigella species, Bordetella pertussis, Brucella species, Neisseria gonorrhoeae, Neisseria meningitides, Pasteurella septica, Vibrio cholera.

Amoxicillin is susceptible to degradation by betalactamase and therefore the spectrum of activity of AMOXSAN ® does not include organisms which produce these enzymes, including resistant staphylococci and all strains of Pseudomonas, Klebsiella and Enterobacter.

Dossage

Posology and method of administration AMOXSAN® Dispersible Tablet may be given without regard to meals.
Dissolve one dispersible tablet in approximately one spoonful of drinking water, wait for about 50 seconds until the tablet is completely dispersed into small granules. The suspension may be directly given to patient, followed by drinking water. Usual dosage for the treatment of infection: • Adults and children over 40 kg: for severe infections, 875 mg every 12 hours or 500 mg three times daily. • Gonorrhoea: single 3 g dose. • Children's dosage (Children under 40 kg) Standard children's dosage: 125 mg three times daily, increasing to 250 mg three times daily for more severe infections. Note: Moderate infection are certain infection without complication such as septicemia or bactericemia. Severe infection are certain infection with complication such as septicemia or bactericemia.

Patients with renal impairment
In renal impairment the excretion of the antibiotic will be delayed and, depending on the degree of impairment, it may be necessary to reduce the total daily dosage according to the following scheme :
Adults and Children over 40 kg
a. Mild impairment (creatinine clearance > 30 mL/min) : No change in dosage
b. Moderate impairment (creatinine 10- 30 mL/min) : 500 mg b.i.d maximum
c. Severe impairment (creatinineclearance) : 500 mg/day maximum
d. There are currently no dosing recommendations for pediatric patients with impaired renal function.

Patients receiving haemodialysis
Dosing as for patients with severe renal impairment (creatinine clearance < 10 mL/min). They should receive an additional dose both during and at the end of dialysis. Amoxicillin is removed from the circulation by haemodialysis. Therefore, one additional dose (500 mg for adults or 15 mg/kg for children under 40 kg) may be administered during dialysis and at the end of each dialysis. It should be recognized that in the treatment of chronic urinary tract infections, frequent bacteriological and clinical appraisals are necessary. Smaller doses than those recommended above should not be used. Even higher doses may be needed at the times. In stubborn infections, therapy may be required for several weeks. It may be necessary to continue clinical and/or bacteriological follow-up for several months after cessation of therapy. Except for gonorrhea, treatment should be continued for a minimum of 48 to 72 hours beyond the time that the patient becomes symptomatic or evidence of bacterial eradication has been obtained. It is recommended that there be at least 10 days treatment for any infection caused by Streptococcus pyogeness to prevent the occurrence of acute rheumatic fever. Parenteral therapy is indicated if the oral route is considered impracticable or unsuitable, and particularly for the urgent treatment of severe infection.

Precaution

- Before initiating therapy with Amoxicillin, careful inquiry should be made concerning previous hypersensitivity reactions to penicillin.
- Periodic assessment of renal, hepatic and hematopoietic functions should be made during prolonged therapy. - Patient with renal disorder must be monitored for its plasma and urine level.
- Patient with renal disorder must be necessary to reduce the total daily unit amoxicillin dosage.
- As with other antibiotics, Amoxicillin administration may cause superinfection (the common causes are Pseudomonas, Enterobacterium, S. aureus and Candida). If it occurs, treatment should be discontinued and appropriate therapy should be instituted.
- Not for meningitis or body joint treatment (since oral Amoxicillin does not penetrate the cerebrospinal or sinovial liquid).
- Caution should be taken when this drug is administered to patients with lymphatic leukemia due to Amoxicillininduced skin rash susceptibility.
- It may be necessary to reduce the total daily unit amoxicillin dosage accordingly for patients with renal disorder.
- This product contains mannitol; it may cause osmotic diarrhea in some patients.
- Patients with infections mononucleosis (glandular fever), lymphatic leukaemia and possibly with HIV infection are particularly prone to developing erythematous rashes with amoxicillin. Amoxicillin should be discontinued if a skin rash occurs.

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BAQUINOR 250

Category

Antibiotics & Chemotherapeutics

Type

Quinolones

Package

Dus fill 2 strips @ 10 tablets.
No. Reg .: DKL9122211517A1

Composition

Each film-coated tablet contains Ciprofloxacin
Hydrochloride equivalent to 250 mg Ciprofloxacin.

Indication

BAQUINOR®
 Indicated for the treatment of infection
Caused by the sensitive strains of the
Microorganisms under the following conditions:
- Lower respiratory tract infections caused:
E. coli, K. pneumoniae, E. cloacae, Pr. Mirabilis, Ps.
Aeruginosa, H. influenzae, H. parainfluenzae.
- Skin and soft tissue infections caused:
E. coli, K. pneumoniae, E. cloacae, Pr. Mirabilis, Pr.
Vulgaris, P. stuartii, M. morganii, C. freundii, Ps. Aeruginosa,
Staph. Aureus (the resulting strain as well
Which does not produce penicillinase), Staph.
Epidermidis and Str. Pyogenes.
- Bone and joint infections caused:
E. cloacae, S. marcescens and Ps. Aeruginosa.
- Urinary tract infections caused:
E. coli, K. pneumoniae, E. cloacae, S. marcescens, Pr.
Mirabilis, P. rettgeri, M. morganii, C. diversus, C. freundii,
Ps. Aeruginosa, Staph. Epidermidis and Str. Faecalis.
- GI infection caused by:
E. coli (enterotoxigenic strains), C. jejuni, S.
Flexneri and S. sonnei.

Dossage

- mild or moderate urinary tract infection: 250 mg,
2 times a day.
Severe urinary tract infection: 500 mg, 2 times daily.
- Airway infections, skin and soft tissue, bones
And mild or moderate joints: 500 mg, 2 times
a day.
Severe infection: 750 mg, 2 times daily.
- GI infection: 500 mg, 2 times daily.
- To obtain adequate levels of osteomyelitis
Acute then the gift should not be less than
750 mg, 2 times a day.
- Dosage for patients with impaired renal function:

When creatinine clearance less than 20 ml / min then
The recommended normal dose should be given once
Or halved if given 2 times a day.
- Or according to doctor's instructions.

Precaution

- The absorption of tablets is affected by the antacids
Containing aluminum or magnesium hydroxide.
So do not get both drugs together,
But must be given 1 to 2 hours before or
After administration of antacids.
- When Ciprofloxacin (1500 mg or more daily) is given
Along with theophylline, there will be an increase
The theophylline levels in the plasma are not
Desired. If theophylline is inevitable,
Theophylline in plasma should be monitored, if
The dose of theophylline should be reduced.
- Consideration of possible interactions should be considered
When administered together with probenecid,
Clindamycin and metronidazole.

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BAQUINOR FORTE

Category

Antibiotics & Chemotherapeutics

Type

Quinolones

Package

Dus fill 2 strips @ 10 caplets.
No. Reg .: DKL9222212809A1

Composition

Ciprofloxacin Hydrochloride equivalent to 500 mg Ciprofloxacin.

Indication

For the treatment of infections caused by bacteria
Which are sensitive to Ciprofloxacin such as:
- Urinary tract infections including prostatitis.
- Urethritis and cervicitis gonorrhea.
- Gastrointestinal infections, including typhoid fever
Caused by Salmonella typhosa. Efficacy of Ciprofloxacin
For eradication chronic typhoid carrier yet
is known.
- Airway infections, except cause pneumonia
Streptococcus.
- Skin and soft tissue infections.
- Bone and joint infections.

Dossage

Adult:
- mild / moderate urinary tract infection: 2 x 250 mg daily.
- Urinary tract infections: 2 x 500 mg daily.
- mild / moderate infections of the airways, bones, joints,
Skin and soft tissue: 2 x 250 - 500 mg daily.
- Heavy airway infections, bones, joints, skin and tissues
Soft: 2 x 500 - 750 mg daily.
- Chronic prostatitis: 2 x 500 mg.
- Gastrointestinal infections: 2 x 500 mg.
- Acute gonorrhea: 250 mg single dose.
- To obtain adequate levels of osteomyelitis
Acute, the dose should not be less than 2 x
750 mg a day.
The length of treatment depends on the severity of the infection,
Clinical and bacteriological advances. For acute infection,
The duration of treatment is usually 5 -10 days. In general
Treatment should be continued to a minimum
3 days, after clinical symptoms disappear.
Dosage of renal dysfunction:
When creatinine clearance is less than 20 ml / min, then
The normal dose is given only once a day or if given
2 times a day, the dose should be halved.

Precaution

- If during use fluoroquinolone patients
Experiencing pain, swelling, and inflammation
On the tendon and tendon rupture, then
so that:
• Immediately discontinue use of this drug.
• Contact your doctor immediately to consult
Alternative drug replacement.
• Avoid sports activities and other activities
Which uses the affected tendon.
- Ciprofloxacin should be swallowed with enough water
To prevent kristaluria.
- Careful administration of patients with disorders
Kidney function (see DOSE).
- Giving should not exceed the recommended dosage.
- Ciprofloxacin should be given with caution on
Sufferers in the elderly. In cases of epilepsy and patients
Who have experienced CNS disorders (eg
Low seizure threshold, history of convulsions, flow
Blood to brain decreases and stroke), Ciprofloxacin
Only given if the benefits are greater than
The risk, because such patients might be
Suffering from CNS side effects.
- Although taken in accordance with the prescription, medicine
This can disrupt the patient's response, ability
Driving and running the machine. This disorder
Will be more severe if taken with alcohol.
- Just like any other antimicrobial, term delivery
Long can lead to excessive growth
Of less sensitive microorganisms.
- Avoid suffering from excessive sunlight.
When it happens

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BAQUINOR INFUS

Category

Antibiotics & Chemotherapeutics

Type

Quinolones

Package

Bottle glass infusion with 100 ml netto contents.
No. Reg .: DKL9822226349A1
Softbag infusion with 100 ml netto contents.
No. Reg .: DKL9822226349A2

Composition

Each 100ml contains:
Ciprofloxacin Lactate Monohydrate equivalent to
Ciprofloxacin 200 mg
Water for injection Ad 100 ml

Indication

For treatment of severe infections of inpatients of the house
Pain that can not be given oral or ciprofloxacin
Improper oral administration.
Infections caused by bacteria that are sensitive to
Ciprofloxacin at:
- Urinary tract infections including prostatitis.
- Urethritis and cervicitis gonorrhea.
- Gastrointestinal infections, typhoid fever caused
  By Salmonella typhi.
  Siprofloksasin efficacy for eradication chronic typhoid
  Carrier not yet known.
- Airway infections, except for Strep-
  Tococcus.
- Skin and soft tissue infections.
- Bone and joint infections.

Dossage

Adult:
- Uncomplicated kidney infections and salivary infections -
  Upper and lower urinary tract: 2 x 100 mg daily.
- Other infections: 2 x 200 mg daily.
- Acute gonorrhea and uncomplicated acute cystitis
  In women: a single infusion of 100 mg. After giving
  Intravenous treatment can be forwarded orally.
Elderly patients may be given a lower dose
Depending on the severity of the illness and the clearance
Creatinine.
Dosage in patients with impaired renal function:
When creatinine clearance <20 ml / min, then the normal dose
Only given once a day or if given 2 times a day
Then the dose should be halved.

Precaution

- Careful administration of patients with disruptive-
  Renal function (see dose).
- Giving should not exceed the recommended dosage.
- Ciprofloxacin should be given with caution on
  Elderly people.
- In cases of epilepsy and patients who have been on-
  Nerve disorders of the central nervous system (eg threshold
  Low seizures, history of convulsions, blood flow to the brain
  Reduced and stroke), Ciprofloxacin is only given
  If the benefits outweigh the risks,
  Na such patients may suffer the effects
  Side of the central nervous system.
- Although given according to the prescription, this medicine
  Can disrupt the patient's response, ability
  Driving and running the machine. This disorder
  Will be heavier if given with alcohol.
- Avoid suffering from excessive sunlight -
  An. In the event of phototoxicity treatment should be immediate
  Stopped.

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LEVOCIN 500

Category

Antibiotics & Chemotherapeutics

Type

Quinolones

Package

Box of 3 strips @ 6 tablets
Reg. No.: DKL0222236917B1

Composition

Each film-coated tablet contains:
Levofloxacin Hemihydrate equivalent to 500 mg of Levofloxacin.

Indication

For the treatment of the following infections when due
to Levofloxacin susceptible microorganisms:
- Acute maxillary sinusitis.
- Acute exacerbation of chronic bronchitis.
- Community-acquired pneumonia.
- Urinary tract infections including pyelonephritis mild to
moderate.
- Uncomplicated skin and skin structure infections (mild
to moderate).
CONTRA-INDICATIONS
- Hypersensitivity to Levofloxacin and other quinolone
antimicrobial agents.
- Pregnant women or suspected pregnant, nursing
mothers and children < 18 years of age.

Dossage

- Dosage for patients with normal renal function
(Creatinine clearance> 80 ml / min).

A. Indications: Acute maxillary sinusitis
Dosage: 500 mg every 24 hours
Length of Treatment: 10 -14 days
    
B. Indications: Acute exacerbation of chronic bronchitis
Dosage: 500 mg every 24 hours
Duration of Treatment: 7 days

C. Community-acquired pneumonia
Dosage: 500 mg every 24 hours
Length of Treatment: 7 -14 days

C. Urinary tract infections are complicated
Dosage: 250 mg every 24 hours
Duration of Treatment: 10 days

D. Uncomplicated urinary tract infection
Dosage: 250 mg every 24 hours
Duration of Treatment: 3 days

E. Acute pyelonephritis
Dosage: 250 mg every 24 hours
Duration of Treatment: 10 days

F. Uncomplicated skin infections and skin structure
Dosage: 500 mg every 24 hours
Duration of Treatment: 7 -10 days

- Dosage for people with kidney function disorder
* For acute exacerbation of chronic bronchitis, or community-acquired
Pneumonia, or maxillary sinusitis
Acute or skin infections and skin structure without complications,
Dose as follows:

A. Creatinine Clearance: 10 - 19 (ml / min)
Dose: initial dose of 500 mg, followed by 250 mg every 48 hours

B. Creatinine Clearance: 20 - 49 (ml / min)
Dose: initial dose of 500 mg, followed by 250 mg every 24 hours

C. Creatinine Clearance: 50 - 80 (ml / min)
Dosage: No dosage adjustment is required

D. Creatinine Clearance: Hemodialysis
Dose: initial dose of 500 mg, followed by 250 mg
Every 48 hours

E. Creatinine Clearance: Peritoneal Dialysis Chronic Ambulatory (CAPD) Dose: 500 mg dose, followed by 250 mg every 48 hours

* For urinary tract infections with complications or
Acute pyelonephritis, the dose as follows:

A. Creatinine Clearance: 10 - 19 (ml / min)
Dose: initial dose of 250 mg every 48 hours, followed by 250 mg

B. Creatinine Clearance: 20 (ml / min)
Dosage: No dosage adjustment is required

* For uncomplicated urinary tract infections: no
Required dose adjustment.

Precaution

- If hypersensitivity reactions (skin rash, hives or other skin
reactions, a rapid heartbeat, difficulty in swallowing or
breathing, swelling of the lips, tongue, face, tightness
of the throat, hoarseness) or other symptoms of an
allergic occur, the drug should be discontinued.
- Should be used with caution in patients with renal insufficiency
(creatinine clearance < 80 ml/min), adjustment
of the dosage regimen is necessary to avoid the
accumulation of Levofloxacin.
- Observe caution while operating an automobile or
machinery or performing other tasks requiring coordination.
- To discontinue treatment and inform their physician if
they experience pain, inflammation, or rupture of a
tendon.
- To avoid excessive sunlight while receiving Levofloxacin
and to discontinue therapy if phototoxicity occurs.
- That if they are diabetic and are being treated with
insulin or an oral hypoglycemic agent and hypoglycemic
reaction occurs, they should discontinue Levofloxacin
and consult a physician.
- Should be used with caution in any patient with a
known or suspected central nervous system disorder
that may predispose to seizures or lower the seizure
threshold (e.g., severe cerebral arteriosclerosis,
epilepsy) or in the presence of other risk factors that
may predispose to seizures or lower the seizure
threshold.
- Convulsions and toxic psychoses have been reported
in patients receiving quinolones (including Levofloxacin).
Quinolones may also cause increased intracranial
pressure and central nervous system stimulation which
may lead to restlessness, light-headedness, tremors,
hallucinations, depression, paranoia and nightmares. If
these reactions occur, the drug should be discontinued.
- Serious and fatal hypersensitivity reactions often occur
following the first dose. Some reactions have been
accompanied by urticaria, itching and other serious
skin reactions, dyspnea, respiratory obstruction, angioedema,
hypotension/shock and cardiovascular
collapse. The drug should be discontinued at the first
appearance of a skin rash or any other sign of hypersensitivity.
- Treatment with antibacterial agents (including Levofloxacin)
alters the normal flora of the colon and may
permit overgrowth of clostridia. Studies indicate that a
toxin produced by Clostridium difficile is one primary
cause of colitis.
- Pseudomembranous colitis has been reported with
nearly all antibacterial agents (including Levofloxacin),
and may range in severity from mild to lifethreatening.
Therefore, it is important to consider this
diagnosis in patients who present with diarrhea
subsequent to the administration of any antibacterial
agent.
- Periodic assessment of organ system functions, including
renal, hepatic and hematopoietic is advisable
during prolonged therapy. The patient should drink
sufficient fluids to avoid crystalluria.

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LEVOCIN INFUS

Category

Antibiotics & Chemotherapeutics

Type

Quinolones

Package

Softbag with net contents 100 ml.
Reg. No.: DKL0722243649A1

Composition

Each 100 ml of the solution contains:
Levofloxacin Hemihydrate is equivalent to
Anhydrous Levofloxacin 500 mg
Water for injection ad 100 ml
Osmolarity: 290 mOsm / l

Indication

Treatment of infection for >17 years old sufferers caused by sensitive microorganisms against Levydloxacin as in the following circumstances:
- Acute maxillary sinusitis.
- Acute exacerbation of chronic bronchitis.
- Community-acquired pneumonia.
- Urinary tract infections with complications (including acute pyelonephritis).
- Uncomplicated skin infections and skin structure (mild to moderate).
- Levofloxacin i.v. Is reserved for patients who can not tolerate oral dosage forms.

Dossage

- LEVOCIN is usually given for 7-14 days depending on the severity of the disease. The usual doses in patients with normal renal function are: 250-500 mg once daily (depending on the type, severity of the infection and the sensitivity of the pathogen causing the infection). Initial treatment i.v. After a few days it is possible to be replaced by oral administration according to the condition of the patient.
- Elderly patients and patients with liver damage (but normal kidney function) may receive normal adult doses.
- Dosage for patients with impaired renal function as follows (creatinine clearance <50 ml / min).

A. Creatinine Clearance (ml / min):> 50
    Dosage: No dosage adjustment is required

B. Creatinine Clearance (ml / min): 20 - 49
    Initial Dose: 500 mg
    The next dose: 250 mg every 24 hours.

C. Creatinine Clearance (ml / min): 10 -19
    Initial Dose: 500 mg
    The next dose: 125 mg every 24 hours.

D. Creatinine Clearance (ml / min): <10 (including hemodialysis and CAPD)
    Initial Dose: 500 mg
    The next dose: 125 mg every 24 hours

Levofloxacin i.v. Should be given slowly through infusion i.v. For a dose of 500 mg (100 ml) infusion should not be less than 60 minutes. Protection of light during infusion is not necessary.

Precaution

- If hypersensitivity reactions (skin rash, hives or other skin reactions, a rapid heartbeat, difficulty in swallowing or breathing, swelling of the lips, tongue, face, tightness in the throat, hoarseness) or other symptoms of allergy occur, the drug should be discontinued.
- Should be used with caution in patients with renal insufficiency (creatinine clearance < 50 ml/minute), adjustment of the dosage regimen is necessary to avoid the accumulation of Levofloxacin.
- Observe caution while operating an automobile or machinery or performing other tasks requiring coordination.
- Discontinue treatment and inform their physician if they experience pain, inflammation, or rupture of a tendon.
- Avoid excessive sunlight while receiving Levofloxacin and discontinue therapy if phototoxicity occurs.
- If they are diabetic and are being treated with insulin or an oral hypoglycemic agent and hypoglycemic reaction occurs, they should discontinue Levofloxacin and consult a physician.
- Should be used with caution in any patient with a known or suspected central nervous system disorder that may predispose to seizures or lower the seizure threshold (e.g., severe cerebral arteriosclerosis, epilepsy) or in the presence of other risk factors that may predispose to seizure or lower the seizure threshold.
- Convulsion and toxic psychoses have been reported in patients receiving quinolones (including Levofloxacin). Quinolones may also cause increased intracranial pressure and central nervous system stimulation which may lead to restlessness, lightheadedness, tremors, hallucinations, depression, paranoia and nightmares. If these reactions occur, the drug should be discontinued.
- Serious and fatal hypersensitivity reactions often occur following the first dose. Some reactions have been accompanied by urticaria, itching and other serious skin reactions, dyspnea, respiratory obstruction,
angioedema, hypotension, shock and cardiovascular collapse. The drug should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity.
- Treatment with antibacterial agents (including Levofloxacin) alters the normal flora of the colon and may permit overgrowth of clostridia. Studies indicate that a toxin produced by Clostridium difficile is one primary cause of colitis.
- Pseudomembranous colitis has been reported with nearly all antibacterial agents (including Levofloxacin), and may range in severity from mild to life threatening. Therefore, it is important to consider this
diagnosis in patients who present with diarrhea subsequent to the administration of any other anti bacterial agent.
- Periodic assessment of organ system functions, including renal, hepatic and hematopoietic is advisable during prolonged therapy. The patient should drink sufficient fluids to avoid crystalluria.

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RESFLOK

Category

Antibiotics & Chemotherapeutics

Type

Quinolones

Package

Box of 3 strips @ 6 tablets.
Reg. No.: DKL9822226017A1

Composition

Sparfloxacin 200 mg

Indication

Lower resp tract infection, community-acquired pneumonia, acute exacerbation of COPD.

Dossage

Adult Community-acquired pneumonia & acute exacerbation of COPD Initially 400 mg as a single dose on day 1, then 200 mg daily for 10 days.

Precaution

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